Role of DNA Double-strand Break Repair Genes in Cell Proliferation under Low Dose-rate Irradiation Conditions

DNA Double-Strand Break Repair

ownloade C regulates a myriad of genes controlling cell proliferation, metabolism, differentiation, and apoptosis. lso controls the expression of DNA double-strand break (DSB) repair genes and therefore may be a ial target for anticancer therapy to sensitize cancer cells to DNA damage or prevent genetic instability. report, we studied whether MYC binds to DSB repair gene promoters and modulates...

DNA double-strand break repair

The integrity of genomic DNA is crucial for its function. And yet, DNA in living cells is inherently unstable. It is subject to mechanical stress and to many types of chemical modification that may lead to breaks in one or both strands of the double helix. Within the cell, reactive oxygen species generated by normal respiratory metabolism can cause double-strand breaks, as can stalled DNA repli...

The Role of BRCA1 in DNA Double-strand Break Repair

The study of dose gamma rays of 192Ir source on DNA single strand break (SSB) and DNA double strand break (DSB) in soft tissue phantom

Introduction: Passage of ionizing radiation through the organs of living creatures develops clusters of damaged nucleotides inside the DNA rounds. 192Ir Gamma source is one of the most widely used sources in brachytherapy of cervical and prostate cancer. Thus, in this research, we investigated the flux of photons and its resulting secondary electrons, the single-strand break (S...

Repair of DNA Double-Strand Breaks in Mouse Tissues after Low dose irradiation

A lot is known about a cell’s reaction to high doses of ionizing radiation (IR), but the impact of low doses (< 50 mGy) is not well understood. There is increasing evidence that different cellular responses may play a role after low dose IR and it becomes obvious that the results from high dose studies cannot be transferred directly to the low dose range. The most deleterious form of IR induced...